Derek Lowe has another interesting find in Don't Talk To Yourself So Much:
I've been re-reading Francis Crick's memoir What Mad Pursuit, and this passage struck me:
". . .it is important not to believe too strongly in one's own arguments. This particularly applies to negative arguments, arguments that suggest that a particular approach should certainly not be tried since it is bound to fail. . .While one should certainly try to think which lines are worth pursuing and which are not, it is wise to be very cautious about one's own arguments, especially when the subject is an important one, since then the cost of missing a useful approach is high. . .
Be sensible but don't be too impressed by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach."
While Derek focuses on life in the lab, this maxim applies to any pursuit - very much along the lines of "don't take yourself so darned seriously." It is so easy to fall into the trap of "that will never work" with all its attendant explanations and justifications. Of course, due caution is appropriate, particularly in a chemical lab. But this shouldn't keep you from trying. I've finally tossed an idea to a friend about working together, and she didn't say I was crazy (Thanks LexThink).
Give voice to the idea. Make the attempt. It's the only way to find out.